A call was received at 8pm yesterday evening to reports of a road traffic collision on Windmill Hill on Rough Close.
Three crews from Longton, including the rescue tender, were called to the incident which involved two vehicles.
Firefighters used specialist cutting equipment to extricate two casualties who were trapped inside the vehicles. Three casualties were then transported to the University Hospital of North Staffordshire via land ambulance.
The incident closed at 9.10pm.